Confira a lista de músicas que estarão presentes em Guitar Hero 5:
- 3 Doors Down - "Kryptonite"
- A Perfect Circle - "Judith"
- AFI - "Medicate"
- Arctic Monkeys - "Brainstorm"
- Attack! Attack! UK - "You and Me"
- Band Of Horses - "Cigarettes, Wedding Bands"
- Beastie Boys - "Gratitude"
- Beck - "Gamma Ray"
- Billy Idol - "Dancing with Myself"
- Billy Squier - "Lonely is the Night"
- Blink-182 - "The Rock Show"
- Blur - "Song 2"
- Bob Dylan - "All Along the Watchtower"
- Bon Jovi - "You Give Love A Bad Name"
- Brand New - "Sowing Season"
- Bush - "Comedown"
- Children Of Bodom - "Done With Everything, Die For Nothing"
- Coldplay - "In My Place"
- Darker My Love - "Blue Day"
- Darkest Hour - "Demon(s)"
- David Bowie - "Fame"
- Deep Purple - "Woman From Tokyo ('99 Remix)"
- Dire Straits - "Sultans of Swing"
- Duran Duran - "Hungry Like The Wolf"
- Eagles Of Death Metal - "Wannabe in L.A."
- Elliott Smith - "L.A."
- Elton John - "Saturday Night's Alright For Fighting"
- Face To Face - "Disconnected"
- Garbage - "Only Happy When It Rains"
- Gorillaz - "Feel Good Inc."
- Gov't Mule - "Streamline Woman"
- Grand Funk Railroad - "We're an American Band"
- Iggy Pop - "Lust For Life"
- Iron Maiden - "2 Minutes to Midnight"
- Jeff Beck - "Scatterbrain"
- Jimmy Eat World - "Bleed American"
- John Mellencamp - "Hurts So Good"
- Johnny Cash - "Ring of Fire"
- Kaiser Chiefs - "Never Miss a Beat"
- King Crimson - "21st Century Schizoid Man"
- Kings Of Leon - "Sex on Fire"
- Kiss - "Shout it Out Loud"
- Love and Rockets - "Mirror People"
- Megadeth - "Sweating Bullets"
- Mötley Crüe - "Looks That Kill"
- Muse - "Plug in Baby"
- My Morning Jacket - "One Big Holiday"
- Nirvana - "Lithium"
- Nirvana - "Smells Like Teen Spirit"
- No Doubt - "Ex-Girlfriend"
- Peter Frampton - "Do You Feel Like We Do (Live)"
- Public Enemy Featuring Zakk Wylde - "Bring the Noise 20xx"
- Queen & David Bowie - "Under Pressure"
- Queens Of The Stone Age - "Make it With Chu"
- Rammstein - "Du Hast"
- Rose Hill Drive - "Sneak Out"
- Rush - "The Spirit of Radio (Live, 2008)"
- Santana - "No One To Depend On (Live)"
- Scars On Broadway - "They Say"
- Screaming Trees - "Nearly Lost You"
- Smashing Pumpkins - "Bullet With Butterfly Wings"
- Sonic Youth - "Incinerate"
- Spacehog - "In the Meantime"
- Stevie Wonder - "Superstition"
- Sublime - "What I Got"
- Sunny Day Real Estate - "Seven"
- T. Rex - "20th Century Boy"
- The Bronx - "Six Days a Week"
- The Derek Trucks Band - "Younk Funk"
- The Duke Spirit - "Send a Little Love Token"
- The Killers - "All the Pretty Faces"
- The Police - "So Lonely"
- The Raconteurs - "Steady As She Goes"
- The Rolling Stones - "Sympathy for the Devil"
- The Sword - "Maiden, Mother & Crone"
- The White Stripes - "Blue Orchid"
- Thin Lizzy - "Jailbreak"
- Thrice - "Deadbolt"
- Tom Petty - "Runnin' Down a Dream"
- Tom Petty & The Heartbreakers - "American Girl"
- TV On The Radio - "Wolf Like Me"
- Vampire Weekend - "A-Punk"
- Weezer - "Why Bother?"
- Wild Cherry - "Play That Funky Music"
- Wolfmother - "Back Round"
Além disso, estarão presentes como personagens os artistas Matt Bellamy (Muse), Johnny Cash, Kurt Cobain (Nirvana) e Shirley Manson (Garbage). As informações são do site Joystiq, mas ainda não podem ser consideradas como oficiais, até que a desenvolvedora confirme.
